Mac User can delete Profile
Are you referring to individual profiles or the MobiControl Management profile?
Mobi Control Management Profile.. i tried to add password through Custom Profile, but i hasnt work yet..
This is standard behavior of Management Profiles. If you want to prevent their removal, you have to enroll in Apple Business Manager and use DEP to enroll your devices. In your Add Device Rule, under the Device Enrollment Program tab, you'll see an option to "Prevent unenrollment".
If your MacOS device was bought from an Apple reseller which is a also registered DEP reseller, you can request them to add your device to your DEP account. It was reported on the web that machines bought in 2011 had successfully been added back to DEP account of its owner.
At the moment, MacOS devices cannot be added to a DEP account with other means, such as using Apple Configurator 2.5+, that can be used to add iOS devices to DEP account. There's rumour that Apple is considering a solution now.